Harald Jungnickel oral presentation (SN3-Wed2-2-4)
Aluminum containing nanoparticles and their influence on vitamin A and D metabolism
Federal Institute for Risk Assessment, Max-Dohrn Str. 8-10, 10589 Berlin, Germany
Aluminum is the third most abundant element on earth and extensively used in different consumer products, e.g. food packaging, coloring agents and pharmaceuticals. Studies that demonstrate neurotoxicity and a possible link to Alzheimer’s disease trigger some concerns about potential health risks due to high aluminum intake. Characterization of the physico-chemical behavior of aluminum in complex matrices remains a major challenge in analytical chemistry. However, understanding of the underlying intake mechanisms of aluminum in humans and its mediated toxicity is of high importance in human risk assessment. The complexation behavior of aluminum reveals highly sophisticated and complicates the elucidation of uptake mechanisms. Vitamin D is known to mediate the bioavailability of essential inorganic elements like calcium and magnesium. Vitamin D also enhances the uptake of known toxic metals like aluminum or lead. Furthermore, the influence of vitamin D on uptake and metabolism of retinol was confirmed . The use of aluminum in cosmetic products therefore raises the question regarding a potential interaction between aluminum and vitamin A and D metabolism. Therefore, we investigated the uptake and distribution of Al2O3 and Al0 nanoparticles in the human keratinocyte cell line HaCaT and a possible interaction of the two aluminum species with vitamin A and D analogs. We used Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) for the characterization of aluminum carbonate and phosphate complex formation to get further insights into possible uptake mechanisms.